Synthesis and In Vitro Profiling of Psilocin Derivatives: Improved Stability and Synthetic Properties
Journal of Medicinal Chemistry March 20, 2025 Julia Eklund, Ulf Bremberg, Jessica Larsson et al. 4 citations
Psilocin ester prodrugs and psilocin salts may offer simpler and more stable alternatives to current medical-grade psilocybin production. A library of 15 psilocin ester prodrugs and six psilocin salts was synthesized and evaluated for ease of synthesis, chemical stability, and metabolic conversion. Several compounds showed desirable storage and handling stability and rapid metabolic conversion to psilocin, with potential advantages over psilocybin. These findings introduce viable options for future development in psilocybin therapy.