Opposite effects of intraventricular serotonin and bufotenin on rat startle responses.
Pharmacology, biochemistry, and behavior January 1, 1975 M A Geyer, J D Warbritton, D B Menkes et al. 34 citations
Rat startle responses to air puffs were measured during infusion of serotonin (5-HT), a hallucinogenic compound (5-HDMT), or saline. Serotonin reduced startle magnitude in a dose-dependent way, while the hallucinogen increased startle responses. Neither compound specifically affected sensitization or habituation. The findings suggest a central serotonin system that promotes behavioral inhibition, which indoleamine hallucinogens may oppose.