Exploring serotonergic psychedelics as a treatment for personality disorders.
Neuropharmacology July 1, 2025 Brennan M Carrithers, Daniel E Roberts, Brandon M Weiss et al. 4 citations
Psychedelic therapy may hold potential for treating personality disorders by promoting adaptive changes in personality, though rigorous research is lacking. This review first examines research on psychedelics in individuals with personality disorders using the DSM-5-TR categorical model, then applies the dimensional DSM-AMPD framework to explore how psychedelics might affect self-functioning, interpersonal functioning, and pathological personality traits. The authors discuss clinical relevance, safety considerations, gaps, and recommendations for treating these complex populations.