Insights on psychedelics: A systematic review of therapeutic effects.
Neuroscience and biobehavioral reviews June 1, 2025 Joshua Kugel, Ruben E Laukkonen, David B Yaden et al. 15 citations
A sudden shift in understanding or perspective that feels true—called insight—is common during psychedelic experiences and is often considered central to their therapeutic value. A systematic review of 98 studies (40 survey, 58 interventional) found that insight was positively correlated with psychedelic dose and was significantly higher after psychedelics in 93% of studies comparing to placebo. Crucially, 86% of studies found that insight was associated with therapeutic improvement, and this relationship was often stronger than that of mystical-type experience. The findings suggest insight's importance for clinical practice and understanding mechanisms of psychedelic therapy, though heterogeneous study designs and possible publication bias limit meta-analytic conclusions.