Synthesis and crystal structures of five fluorinated diphenidine derivatives.
Acta crystallographica. Section E, Crystallographic communications March 1, 2025 Ryan E Mewis, Matthew C Hulme, Jack Marron et al.
Five fluorinated diphenidine derivatives were synthesized and their structures determined using NMR spectroscopy and X-ray crystallography. All five compounds form hydrogen bonds between their quaternary amine hydrogen atoms and chloride ions. Two compounds show N-H⋯Cl distances of 2.21–2.31 Å, while three exhibit shorter distances of 2.07–2.20 Å. The compound with a pyrrolidine ring adopts an envelope conformation, and the one with a piperidine ring adopts a chair conformation. Crystal packing in all five structures involves C-H⋯π interactions, and no π-π interactions are observed.