Diplopterys pubipetala (Malpighiaceae): Insights into Antioxidant, Antibacterial, and Antifungal Activities with Chemical Composition Analysis via UHPLC-MS/MS and GC/MS.
Molecules (Basel, Switzerland) February 18, 2025 Veronica de Melo Sacramento, Vanessa de Andrade Royo, Pedro Henrique Fonseca Veloso et al. 2 citations
Diplopterys pubipetala, a liana from the Brazilian Cerrado used in Ayahuasca, has limited research on its chemical makeup and biological activities. This investigation identified 25 major volatile compounds in its leaves, including ethyl dodecanoate and nonanoic acid, which are known for antifungal, antioxidant, and antimicrobial properties. The crude extract and ethyl acetate fraction demonstrated strong antioxidant capacity, with EC50 values of 9.83 µg/mL and 6.42 µg/mL, respectively. Antifungal effects were observed against Candida species. This is the first comprehensive chemical and biological profile of D. pubipetala, highlighting its therapeutic potential.