Core Instrument Facility, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
Low-dose esketamine may reduce the incidence of intraoperative hypoxaemia during non-intubation thoracoscopic surgery. This randomized controlled trial will assign patients to receive either esketamine or a placebo (normal saline). The main outcomes are the occurrence of hypoxaemia (oxygen saturation ≤90% for at least 10 seconds) and the time until it appears. Secondary outcomes include hypercapnia, inflammatory markers, pain scores, recovery times, and complications. The trial is registered and approved by an ethics committee.
A four-week Qi-based mindfulness therapy (QMT) program significantly reduced symptoms of depression, anxiety, and insomnia in adults with mild-to-moderate depression. In a self-controlled trial with 18 participants aged 18–65, scores on the 17 Hamilton Depression Rating Scale, Hamilton Anxiety Scale, Zung Self-rating Depression Scale, Self-rating Anxiety Scale, and Insomnia Severity Index all decreased significantly after the intervention compared to before. The findings suggest QMT is an effective nonpharmacological treatment for these symptoms in this population.