Effects of Psilocybin on Mouse Brain Microstructure.
AJNR. American journal of neuroradiology June 3, 2025 Paloma C Frautschi, Ajay P Singh, Nicholas A Stowe et al. 2 citations
Psilocybin treatment in male mice led to structural connectivity differences in the frontal association cortex after 72 hours and microstructural changes in the primary visual cortex after 24 hours, as well as in the striatum and hippocampus after 72 hours, including increased mean diffusivity and decreased neurite density. These findings suggest that diffusion microstructure imaging can detect and characterize brain changes induced by psilocybin, offering a potential method to monitor treatment response and identify clinical endpoints for patients with major depressive disorder.