Exploring Psychedelics Pharmacology: A Scoping Review Charting the Course of Psilocybin Pharmacokinetics.
Clinical neuropharmacology Ramiro Manzano-Nunez, Diego A Gomez, Catalina Toledo-Mendoza et al. 3 citations
A scoping review of five controlled clinical trials involving 112 healthy volunteers describes how psilocybin is processed in the body after oral administration. Peak psilocin concentrations in plasma ranged from 8.2 to 37.2 ng/mL, typically reached about two hours after dosing. The elimination half-life varied from 1.2 to 3.3 hours. A strong positive relationship between dose and maximum concentration was observed. No serious adverse events occurred. No studies reported pharmacokinetic data from patients with depression or those transitioning to palliative care, highlighting a gap in research on target populations.