Consistent evidence that brain serotonin 2A receptor binding is positively associated with personality-based risk markers of depression
The British Journal of Psychiatry December 5, 2024 Emma S Høgsted, Vincent Beliveau, Brice Ozenne et al. 4 citations
A positive association between serotonin 2A receptor binding in the brain and inward-directed facets of neuroticism—depression, anxiety, self-consciousness, and vulnerability to stress—was confirmed in a new cohort of 80 healthy volunteers using the tracer [11C]Cimbi-36. This association was independent of the cortisol awakening response, an index of hypothalamic-pituitary-adrenal axis function. The findings suggest that interventions targeting the serotonin 2A receptor, such as psilocybin, might be especially effective when tailored to individuals' neuroticism profiles.