Ayahuasca drinking using a two-bottle choice procedure in male mice.
Scientific reports October 23, 2024 Natali D Kisaki, Yasmim A Serra, Isa R S Rodrigues et al.
Male mice voluntarily drank ayahuasca over water when offered every other day, regardless of concentration. Extending the interval between exposures to every five days reversed this preference, producing aversion to ayahuasca, especially at higher concentrations. Frequency of exposure and concentration together influenced total ayahuasca intake during later re-exposure. These results indicate that both how often and how much ayahuasca is available determine preference in mice, which may inform therapeutic or ritualistic use.