Locus coeruleus co-activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study.
Epilepsia open December 1, 2024 Samantha Weber, Johannes Jungilligens, Selma Aybek et al. 7 citations
Patients with dissociative seizures tend to remain in specific brain states linked to the locus coeruleus rather than switching between them, suggesting that arousal-related impairments in network switching may be a neural mechanism of dissociation. A co-activation pattern analysis of resting-state fMRI in 14 patients and 14 healthy controls identified three locus-coeruleus-related brain states. Patients showed higher state persistence for two of these states compared to controls (Cohen's d = -0.55 and -0.57; p = 0.01 for both). No significant group differences were found when using the red nucleus as a control seed.