Psilocybin administered following extinction sessions does not affect subsequent cocaine cue reinstatement in male and female rats and mice.
Neuroscience November 1, 2024 Veronika Pohořalá, Martin Kuchař, Rainer Spanagel et al. 3 citations
Psilocybin administered immediately after extinction training did not reduce cue-induced cocaine-seeking in male and female mice or rats. In mice (16 female, 19 male) and rats (24 female, 23 male) that had learned to self-administer cocaine, psilocybin injections (1.0 mg/kg in mice; 1.0 or 2.5 mg/kg in rats) following extinction trials failed to attenuate reinstatement of drug-seeking when cues were presented. Both species and sexes showed significant cue-induced reinstatement regardless of psilocybin treatment. The findings indicate that psilocybin, at the doses and regimen tested, is ineffective in altering cocaine-seeking behavior in these animal models, leaving open whether other conditions might prove useful.