Treatment-Related Fluctuation in Guillain-Barre Syndrome With the Acute Motor-Sensory Axonal Neuropathy (AMSAN) Variant: A Case Report.
Cureus July 1, 2024 Elliot Hernandez, David Dominguez, Raul Medina-Rioja et al. 1 citation
A 60-year-old man developed Guillain-Barré syndrome (GBS) two weeks after consuming ayahuasca, with no preceding infection or vaccination. He had progressive limb weakness, areflexia, and the acute motor-sensory axonal neuropathy (AMSAN) variant. Initial treatment with intravenous immunoglobulin improved his strength, but ten days later he experienced a severe relapse requiring ventilatory support, consistent with treatment-related fluctuation. Retreatment with immunoglobulin led to improvement. This case suggests ayahuasca may be a trigger for GBS and highlights the possibility of treatment-related fluctuations in such patients.