Psychedelic 25H-NBOMe attenuates post-sepsis depression in rats.
Neuroscience letters June 21, 2024 Barbara G Ferri, Cintia O De Novais, Viviana C T Rojas et al. 3 citations
In a rat model of sepsis-associated encephalopathy, the psychedelic phenethylamine 25H-NBOMe reduced depressive-like behaviors and signs of neuroinflammation. Rats that underwent cecal ligation and puncture surgery to induce sepsis showed decreased immobility and increased swimming times in the forced swim test after treatment, indicating fewer depressive symptoms. The compound also increased head-twitch responses, confirming its psychoactive effects, and lowered GFAP expression in the prefrontal cortex, suggesting reduced astrogliosis. The findings indicate that 25H-NBOMe can alleviate post-sepsis depression and neuroinflammation, but its psychedelic properties warrant investigation of similar compounds with fewer psychoactive effects.