Effects of psilocybin on body weight, body composition, and metabolites in male and female mice.
Physiology & behavior October 1, 2024 Jasmine Shakir, Megan Pedicini, Brianna C Bullock et al. 5 citations
A single dose of psilocybin increased body weight in both male and female mice during the days immediately after treatment, without affecting how much they ate or drank. The weight gain was accompanied by increased lean and water mass in males, with a similar trend in females. Blocking the 5-HT2A/2C receptor with ketanserin did not prevent this effect. Blood tests showed elevated creatine kinase, aspartate aminotransferase, and chloride in treated mice. These results begin to clarify how psilocybin may influence body weight and metabolism, which is important for its safe use in clinical and non-clinical settings.