Brain-based correlates of antidepressant response to ketamine: a comprehensive systematic review of neuroimaging studies.
The lancet. Psychiatry October 1, 2023 Gustavo C Medeiros, Malcolm Matheson, Isabella Demo et al. 38 citations
A systematic review of 69 neuroimaging studies (1751 participants) found no well-replicated biomarker for ketamine's antidepressant response, but identified several promising candidates. Response to ketamine was associated with post-treatment increases in gamma power in frontoparietal regions, increased functional connectivity within the prefrontal cortex, and increased functional activation of the striatum. The review highlights substantial methodological heterogeneity across studies and calls for further investigation of these biomarkers.