Understanding the Mechanisms of Action and Effects of Drugs of Abuse.
Molecules (Basel, Switzerland) June 24, 2023 Daniela-Mădălina Ciucă Anghel, Gabriela Viorela Nițescu, Andreea-Taisia Tiron et al. 69 citations
Drug abuse and addiction affect millions worldwide. This review examines mechanisms and effects of opioids, stimulants, depressants, hallucinogens, and cannabis, covering acute and chronic effects, withdrawal symptoms, and cardiovascular impacts including electrocardiogram changes. It also discusses genetic susceptibility in addictions. The review draws on PubMed, grey literature, and reference lists without time limits. It provides a comprehensive overview to inform evidence-based prevention and intervention strategies.