Modulation of Gut Microbiome in Ecstasy/MDMA-Induced Behavioral and Biochemical Impairment in Rats and Potential of Post-Treatment with Anacyclus pyrethrum L. Aqueous Extract to Mitigate Adverse Effects.
International journal of molecular sciences May 22, 2023 Abdelmounaim Baslam, Abdelfatah Aitbaba, Asmae Lamrani Hanchi et al. 16 citations
MDMA dependence in rats alters the gut microbiome, increasing E. coli and reducing beneficial bacteria like Lactobacillus and Bifidobacter. Treatment with an aqueous extract of Anacyclus pyrethrum reversed these changes, restoring a healthier microbial composition. The findings suggest that modulating the gut microbiome could be a target for treating substance use disorders.