The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex.
Psychopharmacology June 1, 2023 Zi-Hang Tang, Zhi-Peng Yu, Qiong Li et al. 7 citations
A substituted phenethylamine psychedelic, 25C-NBOMe, increases the ratio of excitation to inhibition in the orbitofrontal cortex by enhancing glutamatergic transmission and reducing GABAergic transmission via the 5-HT2A receptor. It also boosts the intrinsic excitability of pyramidal neurons, but not fast-spiking interneurons, through mechanisms involving G protein-gated inwardly rectifying potassium channels and protein kinase C. These effects collectively shift local excitation/inhibition balance toward excitation, which may underlie the therapeutic potential of psychedelics for disorders like obsessive-compulsive disorder.