A Systematic Review and Meta-Analysis Investigating the Efficacy of Various Psychedelic Drugs for the Treatment of Substance Use Disorder.
Healthcare (Basel, Switzerland) October 23, 2025 Eve E Keighley, Eid Abo Hamza, Dalia A Bedewy et al. 1 citation
A meta-analysis of 30 studies found that psychedelic drugs—LSD, psilocybin, ketamine, and ibogaine—are effective treatments for substance use disorder. Ibogaine showed the most prominent effects. There was no significant difference in effectiveness between psychedelic treatment combined with psychotherapy and psychedelic treatment alone.