Structural Basis for Molecular Recognition at Serotonin Receptors
Science March 22, 2013 Chong Wang, Yi Jiang, Jinming Ma et al. 522 citations
Two research teams independently determined the crystal structures of two serotonin receptors bound to antimigraine drugs or a precursor of LSD. The structures show that subtle differences in how ligands bind to these receptors lead to substantial differences in the signals generated and the resulting biological responses. The same ligand can activate one or both of the two main serotonin receptor signaling mechanisms, depending on which specific receptor it binds to.