Stewart H Mostofsky

Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Papers

Psilocybin induces spatially constrained alterations in thalamic functional organizaton and connectivity.

NeuroImage October 15, 2022 Andrew Gaddis, Daniel E Lidstone, Mary Beth Nebel et al. 38 citations

Psilocybin alters the functional organization of distinct thalamic subregions and their connections to cortical networks, particularly the mediodorsal and pulvinar nuclei. Using a novel ICA-based approach in 18 healthy meditators, psilocybin-induced changes in intrathalamic spatial organization correlated with subjective drug effects. Thalamocortical connectivity predominantly decreased with visual and default mode networks. In contrast, treating the thalamus as a single unit showed a non-significant numerical increase in connectivity, suggesting that whole-thalamus analyses may mask focal decreases in specific nuclei that express serotonin 2A receptors.

DOI: 10.1016/j.neuroimage.2022.119434 Full text Psilocybin Functional connectivity Independent component analysis Resting state +10