Dynamic coupling of whole-brain neuronal and neurotransmitter systems
Proceedings of the National Academy of Sciences April 13, 2020 Morten L. Kringelbach, Josephine Cruzat, Joana Cabral et al. 326 citations
By combining multimodal neuroimaging data, a framework was developed that demonstrates the fundamental principles of bidirectional coupling between neuronal and neurotransmitter dynamical systems. The work causally explains the functional effects of stimulating specific serotoninergic receptors (5-HT2AR) with psilocybin in healthy humans. This could lead to a better understanding of why psilocybin shows promise as a therapeutic intervention for neuropsychiatric disorders such as depression, anxiety, and addiction.