Therapeutic use of psilocybin: Practical considerations for dosing and administration
Frontiers in Psychiatry December 1, 2022 Jagpaul Kaur Deol, Caroline A. Maccallum, Lindsay A. Lo et al. 95 citations
Interest in psilocybin as a therapeutic approach has grown rapidly, yet health care professionals lack practical guidance on the topic, especially given the medical complexity and vulnerability of patients who may receive psilocybin-assisted psychotherapy. This article reviews basic psilocybin pharmacology and pharmacokinetics, indications, practical therapeutic strategies such as dosing, administration, and monitoring, and safety considerations including contraindications, adverse events, and drug interactions. The goal is to increase health care professionals' knowledge and comfort to discuss and counsel patients on psilocybin therapy, ultimately improving patient care and safety.