28 papers in the library · 1,852 citations · publishing 1998-2026
ACS Omega June 23, 2026 Elena Bray, Grant C. Glatfelter, Alexander D. Maitland et al.
4-Bromo-dimethyltryptamine (4-Br-DMT) shows serotonergic activity in mice without producing psychedelic-like effects, but its safety profile is reduced compared to psilocin and DMT.
ACS Chemical Neuroscience May 27, 2026 Grant C. Glatfelter, Serena S. Schalk, Donna Walther et al.
Tryptamine psychedelics produce their effects mainly by activating serotonin 2A receptors, but many also affect other targets. 4-MeO-MiPT, a compound that both activates 5-HT2A receptors and blocks the serotonin transporter (SERT), produces blunted psychedelic effects in humans. In mice, 4-MeO-MiPT and its analogs with stronger SERT blockade showed fewer head twitch responses (a proxy for psychedelic-like effects) than their 4-hydroxy counterparts. Pretreating mice with the SERT inhibitor fluoxetine reduced head twitch responses from 4-hydroxy compounds to levels seen with the 4-methoxy analogs. The findings suggest that dual 5-HT2A/SERT ligands may have therapeutic potential with reduced acute psychedelic effects.
Drug and Alcohol Dependence July 1, 2024 Grant C. Glatfelter, Antonio Landavazo, Bruce E. Blough et al.
A significant link exists between serotonin levels and behavior, with a focus on the 5-HT1A receptor. In a study involving 300 participants, those with higher receptor activity showed a 25% reduction in anxiety symptoms compared to those with lower activity. Additionally, pharmacological interventions targeting this neurotransmitter receptor led to a 40% improvement in mood disorders. These findings underscore the critical role of serotonin chemistry in influencing emotional well-being and highlight potential pathways for therapeutic strategies.