Psilocin, A Psychedelic Drug, Exerts Anticonvulsant Effects Against PTZ‐ and MES‐Induced Seizures in Mice via 5‐HT1A and CB1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways
Pharmacology Research & Perspectives February 25, 2025 Mohammad Balabandian, Mohammad Amin Manavi, Ali Lesani et al. 4 citations
Psilocin, the active metabolite of psilocybin, shows anticonvulsant effects in mice at a modest dose of 3 mg/kg. Behavioral seizure models and electrophysiological recordings indicate that psilocin modulates seizure activity. The anticonvulsant effects were diminished by administration of 1-MT, L-NAME, naltrexone, sildenafil, and AM-251, implicating the kynurenine pathway, nitrergic and opioidergic systems, cGMP, and CB1 receptors. Western blotting revealed upregulation of 5-HT1A and downregulation of IDO and CB1 expression. Acute psilocin administration exerts anticonvulsant effects mediated at least partly through these systems.