Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review
BJPsych Open December 23, 2021 Zach Walsh, Özden Merve Mollaahmetoğlu, Joseph M. Rootman et al. 180 citations
A systematic review of 83 studies found that subanesthetic doses of ketamine produce rapid, short-lived antidepressant and anti-suicidal effects. Evidence for other psychiatric conditions is less robust but suggests similarly positive but transient benefits. The conclusions are tentative due to high risk of bias across the included studies. Optimal dosing, administration methods, and best forms of adjunctive psychotherapy require further investigation.