Distributed harmonic patterns of structure-function dependence orchestrate human consciousness
bioRxiv (Cold Spring Harbor Laboratory) August 10, 2020 Andrea I. Luppi, Jakub Vohryzek, Morten L. Kringelbach et al. 26 citations preprint
Consciousness arises from how the brain's structural wiring shapes its dynamic activity. By decomposing resting-state fMRI data into harmonic modes of the human structural connectome, a generalizable signature of lost consciousness emerges—whether from anesthesia or brain injury—while a reversed signature characterizes psychedelic states induced by LSD or ketamine, reflecting decoupling of function from structure. This connectome harmonic approach discriminates between behaviorally indistinguishable brain-injured patients and tracks covert consciousness, linking neurobiology to conscious experience.