The Clinical Potential of Dimethyltryptamine: Breakthroughs into the Other Side of Mental Illness, Neurodegeneration, and Consciousness
Psychoactives February 26, 2024 Frankie A. Colosimo, Philip Borsellino, Reese I. Krider et al. 8 citations
DMT, a naturally occurring psychedelic compound, promotes neuroplasticity—the brain's ability to remodel its neural connections—by stimulating neuritogenesis, the growth of new neuronal branches. It interacts with serotonergic, sigma-1, and trace amine-associated receptors and their signaling pathways. Evidence from animal models and clinical trials suggests DMT can improve mental well-being in depression, anxiety, and PTSD, and may aid learning, memory, and recovery from brain injuries. The compound's potential to enhance neurogenesis, particularly for neurodegenerative conditions, is also explored.