Real-world effectiveness and safety of psychedelic-assisted psychotherapy: Outcomes from a large-scale compassionate use cohort in Switzerland.
Psychiatry research February 2, 2026 T Aboulafia-Brakha, A Buchard, C Mabilais et al. 1 citation
In a real-world clinical setting, a single session of psychedelic-assisted psychotherapy with either LSD or psilocybin was well tolerated and linked to significant reductions in depression and anxiety among adults with treatment-resistant disorders. Symptoms improved substantially, with large effects for depression and moderate effects for anxiety. Cognitive changes included less self-blame, rumination, and catastrophizing, along with more positive refocusing and reappraisal. Adverse effects were mild and temporary, with no serious complications. The findings suggest that both substances can be effective and safe in specialized routine care.