Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue
Life December 15, 2023 Gregory Ian Robinson, Dongping Li, Bo Wang et al. 19 citations
Psilocybin, 4-AcO-DMT, and eugenol significantly reduce levels of the inflammatory markers TNF-α and IFN-γ in human 3D EpiIntestinal tissue, while capsaicin and curcumin decrease these markers to a lesser extent. Psilocybin effectively lowers IL-6, IL-8, MCP-1, and GM-CSF levels, but curcumin, capsaicin, and 4-AcO-DMT have limited effects on these markers. Ketanserin lowers IL-6 and GM-CSF levels but has no effect on TNF-α, IFN-γ, IL-8, or MCP-1. Synergistic effects between 5-HT2A ligands and TRP channel ligands are minimal. The results provide further evidence of the anti-inflammatory effects of psilocybin and eugenol, though more research is needed on mechanisms and therapeutic feasibility for conditions like inflammatory bowel disease.