Hallucinogen-Induced Persisting Perception Disorder: A Case Report.
Cureus September 1, 2023 Javairia Ayyub, Sailaja Nandennagari, Dylan Edelbaum et al. 1 citation
Hallucinogen-persisting perception disorder (HPPD) causes persistent visual distortions, most commonly after lysergic acid diethylamide (LSD) use. A 28-year-old Caucasian male with a history of polysubstance use, including LSD and cannabis, developed classic HPPD symptoms seven months after stopping LSD. Diagnosis required ruling out other causes through laboratory and imaging tests. His symptoms did not improve with antipsychotics, indicating they were not solely due to mental illness. While alpha-2 adrenergic drugs like clonidine and benzodiazepines are considered first-line treatment, the patient showed improvement with lamotrigine, which is the gold standard for treating perceptual disturbances in time and space.