Involvement of Adenosine A2A Receptors in Anxiety-Like Behaviors in Tetrahydrocannabinol-Treated Mice.
Brain and behavior February 1, 2026 Burçin Ün, Zeki Akarsakarya, Özlem Yorulmaz Özü et al.
THC induces anxiety-like behavior in mice, and this effect involves an interaction between the brain's adenosinergic and cannabinoidergic systems. Gene expression patterns showed that THC's effects were partially modulated by changes in the expression of both CB1R and A2A receptors. The data suggest that THC plays a predominant role in this molecular interplay, highlighting the importance of receptor cross talk in modulating anxiety.