Comparative Analysis and Structure Identification of Oxidative Metabolites and Hydrogenation Metabolite Enantiomers for 2-Fluorodeschloroketamine.
Journal of analytical toxicology May 19, 2023 Xuan Luo, Di Zhang, Fang Zhang et al. 2 citations
Using mass spectrometry and theoretical calculations, 17 oxidative metabolites of the drug 2-fluorodeschloroketamine (2-FDCK) were identified in human urine and grouped into four categories. The study clarified how the site of oxidative metabolism relates to the electron cloud density in the molecule. Two mirror-image forms of a related compound, dihydro-2-FDCK, were distinguished using a lab-made reference standard and computational predictions. The work also revealed which enzymes favor particular molecular shapes during hydrogenation in the body. These findings provide a foundation for identifying metabolites of similar ketamine-type drugs.