Frontiers in psychiatry
January 1, 2022
Micaela Tirri, Sabrine Bilel, Raffaella Arfè et al.
17 citations
Psychedelic phenethylamines, especially -NBOMe compounds, impair sensorimotor function, reaction time, and sensory gating in mice more potently than LSD or their 2C analogs. Halogenated derivatives 25I-NBOMe and 25B-NBOMe were the most effective at altering visual and acoustic responses, motor activity, and prepulse inhibition. The rank order of potency showed these -NBOMe compounds were stronger than both 2C analogs and LSD. These sensory impairments affected spontaneous movement and reaction time without changing stimulated motor performance. The findings suggest that -NBOMe compounds pose potential public health risks, particularly for driving or hazardous work requiring intact sensorimotor skills.
International journal of molecular sciences
July 17, 2021
Sabrine Bilel, Micaela Tirri, Raffaella Arfè et al.
A novel psychoactive substance, 1-cyclohexyl-x-methoxybenzene, exists as three stereoisomers (ortho, meta, para) structurally similar to tramadol and phencyclidine. In vitro tests showed all three stereoisomers and tramadol were inactive at mu, kappa, and delta opioid receptors. In mice, systemic administration of the stereoisomers impaired sensorimotor responses, altered spontaneous motor activity, produced modest analgesia, and affected thermoregulation and cardiorespiratory responses, resembling effects of tramadol and phencyclidine. Naloxone only partially prevented visual sensorimotor impairments from the stereoisomers, not other effects. The findings indicate these derivatives cause pharmaco-toxicological effects through both opioid and non-opioid mechanisms, suggesting potential for abuse and harm.
Neuropharmacology
October 1, 2018
Andrea Ossato, Sabrine Bilel, Adolfo Gregori et al.
Methoxetamine (MXE), a dissociative drug similar to ketamine and phencyclidine, alters neurological and sensorimotor functions in mice in a dose-dependent manner. Acute systemic administration of MXE, ketamine, and phencyclidine (0.01–30 mg/kg i.p.) differentially affected visual, acoustic, and tactile responses, thermal and mechanical pain, motor activity, and acoustic startle reactivity. MXE and ketamine (1 and 30 mg/kg i.p.) and phencyclidine (1 and 10 mg/kg i.p.) also significantly affected cardiorespiratory parameters and systolic and diastolic blood pressure. The findings suggest MXE produces effects comparable to its parent compounds, with specificity depending on dose and parameter examined.