Neurotoxicological profile of the hallucinogenic compound 25I-NBOMe.
Scientific reports February 21, 2022 Monika Herian, Adam Wojtas, Marzena Maćkowiak et al. 15 citations
The synthetic hallucinogen 25I-NBOMe crosses the blood-brain barrier easily and accumulates in the brain after repeated doses. In rats, chronic treatment caused DNA damage in brain tissue 72 hours later, but no signs of apoptosis. The number of glial cells decreased in the frontal and medial prefrontal cortex, while neural cells were unaffected. These findings suggest that oxidative DNA damage from 25I-NBOMe may lead to glial cell death, indicating potential brain toxicity from recreational use.