Determination of 3-MeO-PCP in human blood and urine in a fatal intoxication case, with a specific focus on metabolites identification.
Forensic sciences research January 1, 2021 Nadia Arbouche, Pascal Kintz, Cecile Zagdoun et al. 16 citations
A fatal intoxication case involving the new psychoactive substance 3-MeO-PCP is reported. The drug, a potent NMDA receptor agonist, was detected in femoral blood at 3,525 ng/mL and urine at 7,384 ng/mL, a blood concentration exceeding previously reported fatal ranges (50–3,200 ng/mL). For the first time, metabolites were identified in blood, including two newly discovered ones: O-demethyl-piperidine-OH-3-MeO-PCP and O-demethyl-cyclohexyl-OH. However, due to unavailable reference standards, metabolite concentrations could not be measured. Low metabolite-to-parent drug ratios (<1) suggest that testing for metabolites does not extend the detection window for this drug.