Antagonism of 5‐hydroxytryptamine by LSD 25 in the central nervous system: a possible neuronal basis for the actions of LSD 25
British Journal of Pharmacology October 1, 1970 R.j. Boakes, Philip Bradley, Ian Briggs et al. 164 citations
Lysergic acid diethylamide (LSD) antagonizes excitation produced by serotonin (5-HT) and glutamate on certain brain stem neurons in decerebrate cats. When applied directly or intravenously, LSD blocked 5-HT-induced excitation and also blocked glutamate excitation on neurons that could be excited by 5-HT. However, LSD did not affect inhibitory actions of 5-HT, glutamate effects on neurons inhibited by 5-HT, or actions of acetylcholine, noradrenaline, homocysteic acid, glycine, or GABA. Methysergide was a weaker antagonist, and 2-bromo-LSD rarely showed antagonism. The authors propose that antagonism to 5-HT and glutamate excitation may underlie LSD's psychotomimetic effects.