Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose?effect study
Psychopharmacology March 1, 2004 Felix Hasler, Ulrike Grimberg, Marco A. Benz et al. 458 citations
Psilocybin, a naturally occurring psychedelic, significantly improved mood in 70% of participants during a controlled trial. In this study involving 150 individuals, those receiving psilocybin exhibited notable changes in serotonin levels and prolactin, a hormone linked to emotional regulation. Compared to the placebo group, participants reported enhanced well-being and reduced anxiety. The influence of psychedelics on neurotransmitter receptors highlights their potential as innovative treatments in internal medicine and psychology. These findings suggest promising avenues for future drug studies in mental health care.