Determination of psilocin and 4-hydroxyindole-3-acetic acid in plasma by HPLC-ECD and pharmacokinetic profiles of oral and intravenous psilocybin in man
Pharmaceutica Acta Helvetiae June 1, 1997 Felix Hasler, Daniel Bourquin, Rudolf Brenneisen et al. 231 citations
After oral ingestion of psilocybin, the main psychoactive compound in Psilocybe mushrooms, peak plasma levels of its metabolite psilocin occur around 105 minutes, averaging 8.2 ng/ml. Another metabolite, 4HIAA, peaks at about 113 minutes at 150 ng/ml. Intravenous administration produces psilocin peaks within roughly 2 minutes at 12.9 ng/ml, indicating rapid dephosphorylation of psilocybin. 4HIAA was not detected after intravenous dosing. The absolute oral bioavailability of psilocin from psilocybin is estimated at about 53%.