THE EFFECT OF LSD AND RESERPINE ON THE CENTRAL NERVOUS SYSTEM OF THE CAT
The Japanese Journal of Pharmacology January 1, 1958 Hiroshi Takagi, Shigeru Yamamoto, Shuji Takaori et al. 11 citations
Lysergic acid diethylamide (LSD-25) was first synthesized by A. Hofmann in 1943, who noted vertigo and restlessness. Small doses were later reported to produce schizophrenic-like symptoms including thought and speech disturbances, mood changes, hallucinations, and delusions. Gaddum and Woolley demonstrated that LSD antagonizes serotonin in the brain. Meanwhile, chlorpromazine and reserpine showed therapeutic psychiatric effects. The authors used electrophysiological methods to study LSD and reserpine's actions on the central nervous system, recording potential changes from afferent stimulation, and aimed to trace antagonism between LSD and chlorpromazine or reserpine.