Simultaneous analysis of 2Cs, 25-NBOHs, 25-NBOMes and LSD in seized exhibits using liquid chromatography–tandem mass spectrometry: A targeted approach
Forensic Science International May 24, 2019 Xue Wei Sarah Chia, Mei Ching Ong, Yuan Yuan Cheryl Yeo et al. 26 citations
Blotter papers have traditionally been abused with LSD, but new psychedelic phenethylamines like 2C drugs and their N-benzylhydroxy (25-NBOH) and N-2-methoxybenzyl (25-NBOMe) derivatives now appear in the illicit market. GC-MS, the standard for drug analysis, fails for thermally labile 25-NBOH drugs because they degrade into 2C drugs during analysis. A non-thermal LC-MS/MS method was developed and validated to simultaneously identify twelve phenethylamines, their derivatives, and LSD without thermal degradation. The method was applied to seized blotter papers and Ecstasy tablets.