Ayahuasca Improves Self-perception of Speech Performance in Subjects With Social Anxiety Disorder
Journal of Clinical Psychopharmacology June 23, 2021 Rafael G. Dos Santos, Flávia de Lima Osório, Juliana Mendes Rocha et al. 85 citations
Ayahuasca, a classic hallucinogen with anxiolytic and antidepressive properties, improved self-perception of speech performance in individuals with social anxiety disorder. In a pilot, proof-of-concept, randomized, parallel-group trial with 17 volunteers, ayahuasca significantly increased positive self-statements during a public-speaking test compared with placebo, alongside increased somatic symptoms such as nausea and gastrointestinal discomfort. The drug did not significantly alter task-related anxiety or recognition of emotions in facial expressions, suggesting a specific cognitive effect on speech performance. Ayahuasca was well tolerated overall, and further research is needed to understand the mechanisms involved.