Ayahuasca and debut of psychosis, description of a clinical case
European Psychiatry April 1, 2025 E. E. Morales Castellano, P. Rivero Rodríguez, Marina Martínez Grimal et al.
Ayahuasca, a hallucinogenic brew used traditionally in Amazonian ceremonies, can trigger psychotic episodes in people with a history of psychiatric disorders. This case report describes a patient who developed a psychosis requiring hospitalization after consuming ayahuasca, with symptoms including hallucinations and delusions. Treatment with antipsychotics led to complete symptom resolution. The authors emphasize that hallucinogens may interact negatively with antipsychotic medications, reducing treatment effectiveness or causing adverse effects. Given ayahuasca's increasing use in developed societies, the report highlights the need for regulation, research, and psychoeducation about its potential risks, especially for vulnerable individuals.