AMT (3‐(2‐aminopropyl)indole) and 5‐IT (5‐(2‐aminopropyl)indole): an analytical challenge and implications for forensic analysis
Drug Testing and Analysis October 5, 2012 Simon Elliott, Simon D. Brandt, Sally Freeman et al. 36 citations
5-(2-Aminopropyl)indole (5-IT) and 3-(2-aminopropyl)indole (α-methyltryptamine, AMT) are isomeric substances that are difficult to differentiate under routine analytical conditions, especially without reference material. Subtle differences in mass spectral and UV conditions can facilitate their differentiation. Analyses included 1H and 13C NMR, GC-EI/CI ion trap MS, and several U/HPLC-DAD and HPLC-MS methods. AMT was detected in a number of fatal intoxications, and there is a potential risk of misidentification when dealing with both substances.