Psychedelics, OCD and Related Disorders: Setting methodological strategies for future studies
Journal of Obsessive-Compulsive and Related Disorders March 19, 2025 Rodolfo Leuzzi, Giovanni Tardivo, Luca Pellegrini et al. 3 citations
Only two published and seven unpublished studies have investigated psychedelics for Obsessive-Compulsive and Related Disorders. A systematic review found a critical risk of bias in all studies, mainly due to lack of adequate control conditions, expectation bias among participants, and poor blinding. Unpublished studies showed similar problems but also implemented promising strategies like blinded raters, credible controls such as virtual reality, lower drug doses, and including only drug-naive subjects. The shortage of unbiased evidence means early potential efficacy justifies further well-designed research.