Effects of MDMA on Extracellular Dopamine and Serotonin Levels in Mice Lacking Dopamine and/or Serotonin Transporters
Current Neuropharmacology March 1, 2011 Yoko Hagino, Yukio Takamatsu, Hideko Yamamoto et al. 64 citations
MDMA increases extracellular dopamine and serotonin in the striatum and prefrontal cortex of mice. In mice lacking both dopamine and serotonin transporters, the dopamine increase in the striatum is absent, while the serotonin increase is greatly reduced. In the prefrontal cortex, MDMA raises dopamine levels regardless of transporter knockout. These findings confirm that MDMA acts on both the dopamine and serotonin transporters to elevate these neurotransmitters.