Neural correlates of working memory in pure and polyvalent ecstasy (MDMA) users
Neuroreport October 1, 2003 Jörg Daumann, Ralph Schnitker, Jürgen Weidemann et al. 46 citations
Working memory performance and brain activation were examined in eight abstinent people who used only MDMA (ecstasy), a group who used MDMA plus other drugs, and non-users. Pure MDMA users showed lower brain activation than controls and polyvalent users, particularly in the inferior temporal regions, angular gyrus, and striate cortex. Polyvalent users did not differ from controls. The findings suggest that altered brain activation during cognitive tasks may be primarily linked to prior MDMA use, and that concomitant use of other drugs may modify this effect.