MDMA (ecstasy) causes a strong increase in blood oxytocin levels and enhances feelings of prosociality in healthy people. The changes in prosocial feelings are more closely tied to changes in oxytocin than to changes in MDMA concentration in the blood. This suggests that oxytocin release may be a key mechanism behind the drug's characteristic social effects.
Mindfulness-based programmes reduce psychological distress (anxiety and depression) in community adults who volunteer to participate, with a small to moderate effect size. The analysis of 13 randomized controlled trials with 2,371 participants from 8 countries found a standardized mean difference of -0.32, with high confidence in the result. The effect was not clearly influenced by participants' baseline distress level, gender, age, education, or dispositional mindfulness. More research is needed to understand why outcomes vary between individuals.
Taking MDMA and ethanol together does not worsen the effects of either drug alone. While the impairment caused by each drug condition was relatively moderate, all drug conditions significantly impaired cognitive function.